By Jacqueline A. Hubbard,Devin K. Binder
Epilepsy is a devastating workforce of neurological problems characterised via periodic and unpredictable seizure job within the mind. there's a severe want for brand spanking new medications and ways given than at the very least one-third of all epilepsy sufferers aren't made freed from seizures by means of present medicinal drugs and develop into "medically refractory". a lot of epilepsy learn has fascinated by neuronal healing goals, yet present antiepileptic medicines frequently reason serious cognitive, developmental, and behavioral unwanted side effects. fresh findings point out a severe contribution of astrocytes, star-shaped glial cells within the mind, to neuronal and community excitability and seizure job. additionally, many vital mobile and molecular alterations take place in astrocytes in epileptic tissue in either people and animal versions of epilepsy. The objective of Astrocytes and Epilepsy is to comprehensively evaluate fascinating findings linking alterations in astrocytes to useful alterations liable for epilepsy for the 1st time in booklet layout. those insights into astrocyte contribution to seizure susceptibility point out that astrocytes may perhaps signify a huge new healing objective within the keep watch over of epilepsy.
Astrocytes and Epilepsy comprises history explanatory textual content on astrocyte morphology and body structure, epilepsy versions and syndromes, and proof from either human tissue reviews and animal versions linking sensible alterations in astrocytes to epilepsy. fantastically labelled diagrams are provided and proper figures from the literature are reproduced to clarify key findings and ideas during this swiftly rising box. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators in addition to neurologists and different experts taking care of sufferers with epilepsy.
- Presents the 1st accomplished ebook to synthesize ancient and up to date examine on astrocytes and epilepsy into one coherent volume
- Provides an exceptional source at the box of astrocyte biology and astrocyte-neuron interactions
- Details strength healing goals, together with chapters on hole junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation
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Additional resources for Astrocytes and Epilepsy
Astrocytes and Epilepsy by Jacqueline A. Hubbard,Devin K. Binder